You might as well be asking what adult beverage one likes; the answers will be varied and many. In that vein I shall give my preference, which is likely not to be worth much.
I'm about your height, though not quite as heavy, but certainly heavier than I should be. My preference for my XDs, 3.3'' .45acp is a CYA Kydex holster. You mention you already use a Kydex holster, so this may be of no help, but I have found the particular "cant" of a Kydex holster is what makes or breaks it with regard to comfort because Kydex is not very forgiving when pressed against flesh.
All of what I'm about to say is based on 4 o'clock carry (I'm too fat for comfortable appendix carry; sitting down is a nightmare), but I've found that a 5-7º "cant" is the sweet-spot for me; more than that and the gun/holster combo becomes irritating. My first Kydex holster, for a Shield 9mm, has a 12º "cant," it's not adjustable, and it's not very comfortable. I do tend to still carry it some, but it is strictly attire dependent; wearing the wrong clothes with that setup is miserable.
I also use a CYA Kydex holster with a .45acp Shield, a 5-7º cant, and quite comfortable. When carrying my Glock 43 it rests in a "Gearcraft" Kydex holster, also with a 5-7º "cant," and also comfortable. The CYA and Gearcraft holsters have adjustable "cants." I would NOT make the same mistake I did with the 9mm Shield and buy a Kydex holster that does not have an adjustable "cant."
One more thing, and this will raise the eyebrows of a multitude of dissenters, but unless you are one of those, and it seems there are many, who recoil in horror at the thought of "pocket carry," don't dismiss that option out of hand. This is another one that is clearly attire dependent because loose clothing is a must for it to be practical, but I find it to be the most comfortable of all options. My Ruger LC9s frequently finds its home in a Desantis nylon holster, all in my right front pocket. A Desantis pocket holster can be had for less that 20 bucks.